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占玲俊
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姓  名: 占玲俊

学  科: 实验动物学

电话/传真:010-67776279

电子邮件: zhanlj#cnilas.org

通讯地址: 北京市朝阳区潘家园南里5号

更多信息: 结核病及结核动物模型研究

简历介绍:

  占玲俊,女,博士,副研究员,硕士生导师。1981年3月生于湖北。2004年和2006年在武汉大学分别获得学士和硕士学位,2009年获北京协和医学院博士学位。主要从事结核病及结核动物模型的比较医学研究。创建了结核动物模型及技术体系24种,利用结核动物模型研究结核病的免疫致病,及药物和疫苗的精准评价模型和体系,在Frontiers in immunology、Frontiers in microbiolog和infection and immunity等杂志上发表文章30余篇,参编论着6部,参与获得教育部、北京市政府和中国实验动物学会的奖项共3项,申请专利2项。

研究领域:

  结核病的免疫机制、结核动物模型研究、比较医学

获奖及荣誉:

?2011年获北京市科学技术三等奖

?2012年中国实验动物学会一等奖

?2015年获教育部科技进步二等奖

承担科研项目情况:

目前主要承担科技部“艾滋、肝炎、结核等重大传染病的实验动物模型”研究专项子课题、外专局引智项目、国家自然基金及院所创新工程等重大研究项目等13项。

代表论着:

10篇第一作者或通讯作者代表文章:

1.Jun Tang, Mengmeng Sun, Guiying Shi, Yanfeng Xu, Yunlin Han, Xiang Li, Wei Dong, Lingjun Zhan* , Chuan Qin*.Toll-Like Receptor 8 Agonist Strengthens the Protective Efficacy of ESAT-6 Immunization to Mycobacterium tuberculosis Infection.Front. Immunol., 24 January 2018 | https://doi.org/10.3389/fimmu.2017.01972

2.Zhan Lingjun,tang jun,sun mengmeng,Chuan Qin*. Animal model for tuberculosis in translational and precision medicine.;2017.8:717. doi: 10.3389/fmicb.2017.00717.

3.ZhanLingjun , tang jun, lin shuzhu, xu yanfeng and xu yuhuan,Chuan Qin*.Prophylactic use of Ganoderma lucidum extract may inhibit Mycobacterium tuberculosis replication in a new mouse model of spontaneous latent tuberculosis infection.2016, Front. Microbiol. 6, p1490.

4.Tangjun, Lingjun Zhan*,Qinchuan*. Inhibition of TLR8 Mediated Signaling Promotes BCG Induced Apoptosis in THP-1 Cells. 2015,Microbial Pathogenesis .

5.Lingjun Zhan, Hai rong Ding, Shuzhu Lin, Jun Tang, Wei Deng, Yanfeng Xu, Yuhuan Xu, Chuan Qin. Experimental Mycobacterium tuberculosis infection in the Chinese tree shrew. FEMS Microbiol Lett. (2014) 1–10.

6.Lingjun Zhan, Linlin Bao, Feng LI, Qi LV, LiLi XU, and Chuan Qin. An optimized Real-time PCR to avoid species/tissue-associated inhibition for H5N1 detection in ferrets and monkeys tissues.The scientific world Journal. 2012.

7.Lingjun Zhan, Wei Deng, Linlin Bao, Qi Lv, Chunmei Ma, Fengdi Li, Lili Xu, Chuan Qin. Higher Immunological Protection of Pandemic 2009 H1N1 Influenza Live Virus Infection than Split Vaccine Against the Homologous Virus for Long Term Immunization in Ferret. Indian Journal of Virology.2012, 23(3): 270-277

8.Lei Yang, Lingjun Zhan?, Dongsheng Zhou*, and Ruifu Yang*, et al. Low salt-induced gene expression profiles analysis of Vibrio parahaemolyticus.? International Journal of Food Microbiology, 2010, 137(1):49-54. (co-author)

9.Lingjun Zhan, Lei Yang?, Dongsheng Zhou*, and Ruifu Yang*.? Direct and negative regulation of the sycO-ypkA-ypoJ operon by cyclic AMP receptor protein (CRP) in Yersinia pestis. BMC Microbiology, 2009 Aug 25;9:178.

10.Lingjun Zhan, Yanping Han, Lei Yang?, Jing Geng, Yingli Li, He Gao, Zhaobiao Guo, Wei Fan, Gang Li, Lianfeng Zhang, Chuan Qin, Dongsheng Zhou*, and Ruifu Yang.*.The Cyclic AMP Receptor Protein, CRP, Is Required for Both Virulence and Expression of the Minimal CRP Regulon in Yersinia pestis Biovar microtus.? Infection and Immunity, 2008, 76: 5028–5037.

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